{"created":"2023-07-27T04:41:32.024211+00:00","id":23927,"links":{},"metadata":{"_buckets":{"deposit":"399f9271-baea-4340-b257-4c48b2fd982c"},"_deposit":{"created_by":3,"id":"23927","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23927"},"status":"published"},"_oai":{"id":"oai:tohoku.repo.nii.ac.jp:00023927","sets":["89:178"]},"author_link":["58954","331255","331257","58963","58959","58957","331258","58953","58962","58958","331253","331261","331262","58960","331254","58955","58956","331259","58961","331252","331256","331260"],"item_4_alternative_title_20":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Localization of C-propeptide of type-I collagen in mineralized tissues"}]},"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"36","bibliographicPageStart":"29","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"東北大学歯学雑誌"}]}]},"item_4_date_62":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-02-05","subitem_date_issued_type":"Created"}]},"item_4_date_63":{"attribute_name":"公開日（投稿完了日）","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-02-05","subitem_date_issued_type":"Created"}]},"item_4_date_65":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-12","subitem_date_issued_type":"Created"}]},"item_4_date_80":{"attribute_name":"更新日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010-02-05","subitem_date_issued_type":"Created"}]},"item_4_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"I型コラーゲンは骨や結合組織,象牙質に豊富に含まれる線維状タンパクである。I型コラーゲンC-プロペプチドはコラーゲン分子への変換に伴って産生され,コラーゲン分子の会合とコラーゲン線維形成にとって必須である。近年,C-プロペプチド単体に様々な作用があることが報告され,特にin vitroにおいて硬組織形成に関与する前駆細胞の分化に抑制的に働くことが報告されている。つまり,硬組織の発達・形成過程での重要性が示されているが,in vivoにおけるC-プロペプチドの局在については明らかとなっていない。本研究では,抗I型コラーゲンC-プロペプチド抗体を用いた免疫組織染色を行い,骨および象牙質,セメント質といった硬組織領域における,それぞれの発現局在について調べ,抗I型コラーゲン抗体を用いたIHCとプロコラーゲンα2(I)鎖のcRNAプローブを用いたin situ hybridizationの結果と比較検討した。胎生期における下顎骨発生,および歯牙の発生過程におけるC-プロペプチドの局在から,骨,象牙質およびセメント質の活発な形成時期にはその基質において集積が認められた。くわえて,ヘルトウィッヒ上皮鞘周囲に認められたI型コラーゲンC-プロペプチドの集積の所見からも,すでに報告されている分化調節機構が骨組織のみならず,象牙質やセメント質の発達過程においても重要である可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"Type I collagen is most commonly existing protein in mammals and particularly abundant in bone, dentin and connective tissues. The C-propeptide is produced while procollagen molecules which are composed of three pro-αchains are assembled to a collagen fibril. It has been suggested that the C-propeptide plays a role to regulate cell differentiation of osteoblasts. However, there is no information about localization in vivo of the C-propeptide in bone and other mineralized tissues such as dentin and cementum. In order to localize the C-propeptide in the mineralized tissues, the present study was designed to investigate their mineralizing processes with immunohistochemistry for the C-propeptide and the type I collagen fibril and with in situ hybridization for the procollagen. Anti-C-propeptide antibody stained the matrix-forming region in osteogenesis, dentinogenesis and cementogenesis. In particular, we found the immunoreactivity around Hertwig's epithelial sheath. The localization of the C-propeptide in vivo may be involved in function to modify cell differentiation on bone tissue and other mineralized tissues as dentin and cementum.","subitem_description_type":"Abstract"}]},"item_4_description_41":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"紀要類","subitem_description_type":"Other"}]},"item_4_description_66":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"1374791 bytes","subitem_description_type":"Other"}]},"item_4_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"331252","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tomizawa, Yasuhiko"}]},{"nameIdentifiers":[{"nameIdentifier":"331253","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuchiya, Masahiro"}]},{"nameIdentifiers":[{"nameIdentifier":"331254","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sato, Shigehisa"}]},{"nameIdentifiers":[{"nameIdentifier":"331255","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, Ichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"331256","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuchiya, Shinobu"}]},{"nameIdentifiers":[{"nameIdentifier":"331257","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Komaki, Ken-ichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"331258","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Akiba, Yosuke"}]},{"nameIdentifiers":[{"nameIdentifier":"331259","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kusunoki, Shin-ichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"331260","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mizoguchi, Itaru"}]},{"nameIdentifiers":[{"nameIdentifier":"331261","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sasano, Yasuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"331262","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Makoto"}]}]},"item_4_publisher_34":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北大学歯学会"}]},"item_4_radio_69":{"attribute_name":"公開範囲","attribute_value_mlt":[{"subitem_radio_item":"学外"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0287-3915","subitem_source_identifier_type":"ISSN"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00081101","subitem_source_identifier_type":"NCID"}]},"item_4_text_72":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"東北大学大学院歯学研究科口腔機能形態学講座加齢歯科学分野 / 東北大学大学院歯学研究科口腔機能形態学講座加齢歯科学分野 / 東北大学大学院歯学研究科口腔機能形態学講座加齢歯科学分野 / 東北大学大学院歯学研究科口腔保健発育学講座顎口腔矯正学分野 / 東北大学大学院歯学研究科口腔保健発育学講座顎口腔矯正学分野 / 東北大学大学院歯学研究科口腔機能形態学講座加齢歯科学分野 / / LSL社 / 北海道医療大学歯学部矯正歯科学分野 / 東北大学大学院歯学研究科顎口腔創建学講座顎口腔形態創建学分野 / 東北大学大学院歯学研究科口腔機能形態学講座加齢歯科学分野@@@Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry@@@Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry@@@Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry@@@Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry@@@Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry@@@Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry@@@Weill Medical College, Cornell University at The Burke Medical Research Institute@@@LSL Co., Ltd.@@@Department of Orthodontics, School of Dentistry, Health Sciences University of Hokkaido@@@Division of Craniofacial Development and Regeneration, Department of Craniofacial Engineering and Regeneration, Tohoku University Graduate School of Dentistry@@@Division of Aging and Geriatric Dentistry, Department of Oral Function and Morphology, Tohoku University Graduate School of Dentistry"}]},"item_4_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"富澤, 康彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土谷, 昌広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"佐藤, 繁久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高橋, 一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土谷, 忍"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小牧, 健一朗"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"秋葉, 陽介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 慎一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"溝口, 到"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笹野, 泰之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡邉, 誠"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-10"}],"displaytype":"detail","filename":"KJ00005128446.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005128446.pdf","url":"https://tohoku.repo.nii.ac.jp/record/23927/files/KJ00005128446.pdf"},"version_id":"f5afe35a-2290-44e1-8e7f-06a2f6d5fa31"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Type I collagen","subitem_subject_scheme":"Other"},{"subitem_subject":"C-propeptide","subitem_subject_scheme":"Other"},{"subitem_subject":"Mineralization","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラットの骨,象牙質およびセメント質におけるI型コラーゲンC-プロペプチドの局在に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラットの骨,象牙質およびセメント質におけるI型コラーゲンC-プロペプチドの局在に関する研究"}]},"item_type_id":"4","owner":"3","path":["178"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-02-05"},"publish_date":"2010-02-05","publish_status":"0","recid":"23927","relation_version_is_last":true,"title":["ラットの骨,象牙質およびセメント質におけるI型コラーゲンC-プロペプチドの局在に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T23:08:21.240249+00:00"}