{"created":"2023-07-27T04:51:46.147614+00:00","id":64120,"links":{},"metadata":{"_buckets":{"deposit":"b8d0038f-1ca0-4344-9cb6-6569f54a5ae0"},"_deposit":{"created_by":3,"id":"64120","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"64120"},"status":"published"},"_oai":{"id":"oai:tohoku.repo.nii.ac.jp:00064120","sets":["86:198"]},"author_link":["152299","152298","152297","152300"],"item_4_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"14","bibliographicPageStart":"9","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Journal of Integrated Field Science"}]}]},"item_4_date_62":{"attribute_name":"登録日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-05-02","subitem_date_issued_type":"Created"}]},"item_4_date_63":{"attribute_name":"公開日（投稿完了日）","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-05-02","subitem_date_issued_type":"Created"}]},"item_4_date_65":{"attribute_name":"発行日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-03","subitem_date_issued_type":"Created"}]},"item_4_date_80":{"attribute_name":"更新日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018-01-04","subitem_date_issued_type":"Created"}]},"item_4_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent interest has focused on the importance of intestinal immunity for the host defense, but to date, not much has been known about the underlying mechanisms. Toll-like receptor (TLR) family plays an important role in the defense through recognizing bacterial pathogen associated molecular patterns (PAMPs). Our research on the bioregulatory function of food products has investigated the immunoregulatory effects of lactic acid bacteria (LAB) via TLRs. Studies in swine, which is expected as a human model, have been examined intestinal immunoregulation by the LAB. Our research has now demonstrated modulation of intestinal immunity mediated by TLRs in Peyer's patches and the mesenteric lymph nodes. On the basis of our study, efforts have also been made to develop an immunoassay system for immunobiotic LAB DNA and cell wall components to evaluate immunoregulation by the LAB via TLRs. The findings in our research activities may provide important clues at the molecular level on TLR signal transduction pathways and recognition mechanisms. They also provide impetus to further delineate the activation mechanism of the innate immune response. In addition, identification of biofactors from LAB with immunoactivity, and better understanding of cytokine induction and intestinal immune regulation hold promise in basic research and development of \"immunobiotic foods\" to prevent specific diseases.","subitem_description_type":"Abstract"}]},"item_4_description_41":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"紀要類(bulletin)","subitem_description_type":"Other"}]},"item_4_description_66":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"778559 bytes","subitem_description_type":"Other"}]},"item_4_publisher_34":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Field Science Center, Graduate School of Agricultural Science, Tohoku University"}]},"item_4_radio_69":{"attribute_name":"公開範囲","attribute_value_mlt":[{"subitem_radio_item":"学外"}]},"item_4_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-6122","subitem_source_identifier_type":"ISSN"}]},"item_4_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12005506","subitem_source_identifier_type":"NCID"}]},"item_4_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KITAZAWA, Haruki"}],"nameIdentifiers":[{"nameIdentifier":"152297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIMOSATO, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"152298","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TOHNO, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"152299","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAITO, Tadao"}],"nameIdentifiers":[{"nameIdentifier":"152300","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-22"}],"displaytype":"detail","filename":"KJ00004370124.pdf","filesize":[{"value":"778.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004370124.pdf","url":"https://tohoku.repo.nii.ac.jp/record/64120/files/KJ00004370124.pdf"},"version_id":"4d0bd34e-9418-4012-b22e-208eb1a9efb9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Swine Intestinal Immunity via Toll-like Receptors and Its Advanced Application to Food Immunology","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Swine Intestinal Immunity via Toll-like Receptors and Its Advanced Application to Food Immunology"}]},"item_type_id":"4","owner":"3","path":["198"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-02"},"publish_date":"2008-05-02","publish_status":"0","recid":"64120","relation_version_is_last":true,"title":["Swine Intestinal Immunity via Toll-like Receptors and Its Advanced Application to Food Immunology"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T13:52:25.069480+00:00"}