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Differential Roles of Beta2 Integrins in Human Crescentic Glomerulonephritis
http://hdl.handle.net/10097/30846
http://hdl.handle.net/10097/30846b036f3a3-9bc8-400c-a4c5-4e335ccc5f75
名前 / ファイル | ライセンス | アクション |
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KJ00004186690.pdf (1.9 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-05-02 | |||||
タイトル | ||||||
タイトル | Differential Roles of Beta2 Integrins in Human Crescentic Glomerulonephritis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ICAM-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | beta2 integrins | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fibrin/fibrinogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | crescentic glomerulonephritis Running Title : Leukocyte integrins in crescentic glomerulonephritis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
OOTAKA, Tetsuya
× OOTAKA, Tetsuya× SATO, Hiroshi× SATO, Toshinobu× ITO, Sadayoshi× SAITO, Takao |
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著者別名 | ||||||
姓名 | 大高, 徹也 | |||||
著者別名 | ||||||
姓名 | 佐藤, 博 | |||||
著者別名 | ||||||
姓名 | 佐藤, 寿伸 | |||||
著者別名 | ||||||
姓名 | 伊藤, 貞嘉 | |||||
著者別名 | ||||||
姓名 | 斉藤, 喬雄 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | An immunohistochemical study was performed to investigate the involvement of beta2 integrins in the glomerular infiltration of leukocytes in different types of human crescentic glomerulonephritis (CrGN). On 51 ethanol-fixed paraffin embedded renal biopsy specimens (34 cases of pauci-immune type and 17 cases of immune-mediated type), the following antigens were evaluated by immunoperoxidase method ; the glomerular (intra-capillary and extra-capillary) expression of ICAM-1, deposition of FRA and infiltration of leukocytes bearing beta2 integrins (LFA-1, CR3 and CR4). ICAM-1 was expressed both in extra-capillary and intra-capillary areas in very early stage of crescent formation and was rapidly decreased with the progression of the stage of crescent. Similarly, infiltration of leukocytes bearing beta2 integrins were observed both in extra-capillary and intra-capillary areas in early stage of crescent formation and were rapidly decreased with the progression of the stage of crescent. In pauci-immune type, the extra-capillary expression of ICAM-1 was significantly correlated with extra-capillary infiltration of LFA-1+cells (γ=0.800, p<0.0001) and CR3+cells (γ=0.791, p<0.0001). The extra-capillary deposition of FRA was also significantly correlated with extra-capillary infiltration of CR3+cells (γ=0.685, p<0.001) and CR4+cells (γ=0. 741, p<0.0001). In both types, the intra-capillary expression of ICAM-1 was significantly correlated with intra-capillary infiltration of LFA-1+cells (γ=0.618, p<0.01 and γ=0.754, p<0.05 respectively). These results suggested that ICAM-1/LFA-1 and ICAM-1/CR3 interaction might be involved in both the extra- and intra-capillary infiltration of leukocytes in pauci-immune CrGN. CR3 and CR4 might also function as fibrin/fibrinogen receptors in extra-capillary lesions in this type. On the other hand, only ICAM-1/LFA-1 interaction might be involved only in the intra-capillary infiltration of leukocytes in immune mediated CrGN. | |||||
書誌情報 |
東北大学医学部保健学科紀要 en : Bulletin of School of Health Sciences Tohoku University 巻 14, 号 1, p. 1-12, 発行日 2005-01-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13488899 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11944693 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | 半月体性腎炎におけるbeta2 integrin 関与の病型間の相違について | |||||
出版者 | ||||||
出版者 | 東北大学医学部保健学科 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 紀要類(bulletin) | |||||
登録日 | ||||||
日付 | 2008-05-02 | |||||
日付タイプ | Created | |||||
公開日(投稿完了日) | ||||||
日付 | 2008-05-02 | |||||
日付タイプ | Created | |||||
発行日 | ||||||
日付 | 2005-01-31 | |||||
日付タイプ | Created | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | 1916676 bytes | |||||
公開範囲 | ||||||
値 | 学外 | |||||
更新日 | ||||||
日付 | 2010-01-27 | |||||
日付タイプ | Created |