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乳癌におけるエストロゲン合成 : アロマターゼの重要性
http://hdl.handle.net/10097/40476
http://hdl.handle.net/10097/40476dcf9eebc-d4d7-435e-aba2-11531c714531
名前 / ファイル | ライセンス | アクション |
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KJ00005127801.pdf (1.5 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-02-05 | |||||
タイトル | ||||||
タイトル | 乳癌におけるエストロゲン合成 : アロマターゼの重要性 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aromatase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Breast cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Estrogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Intracrinology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
鈴木, 貴
× 鈴木, 貴 |
|||||
著者別名 | ||||||
姓名 | SUZUKI, Takashi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It is well known that estrogens play important roles in growth of breast carcinomas. Recent studies have demonstrated that estrogens are locally produced in breast carcinoma tissues by several steroidogenic enzymes including aromatase, and aromatase inhibitors clinically useful for reducing the progression of breast tumors especially in postmenopausal women. In this review, I summarized results of recent studies on aromatase in breast carcinomas, and discuss the biological and/or clinical significance. Aromatase was expressed in various cell types, such as carcinoma cells, intratumoral stromal cells and adipocytes adjacent to the carcinoma, in the breast carcinoma tissue, and aromatase expression in these cells was regulated by various factors such as cell-cell interactions, cytokines and nuclear receptors. Aromatase was involved in not only estrogen production but also inhibition of androgen synthesis in breast carcinoma tissues, and aromatase inhibitors are effective in breast carcinoma patients, possibly due to increasing local androgen with estrogen deprivation. Considering that responsible enzymes in the intratumoral estrogen production are not always the same among breast cancer patients, other estrogen-producing enzymes with an exception of aromatase, may also have important therapeutic potential in breast cancer patients as an endocrine therapy. | |||||
書誌情報 |
東北大学医学部保健学科紀要 en : Bulletin of School of Health Sciences Tohoku University 巻 16, 号 2, p. 59-68, 発行日 2007-07-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1348-8899 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11944693 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | Estrogen Production in Breast Carcinoma : Significance of Aromatase | |||||
出版者 | ||||||
出版者 | 東北大学医学部保健学科 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 紀要類 | |||||
登録日 | ||||||
日付 | 2010-02-05 | |||||
日付タイプ | Created | |||||
公開日(投稿完了日) | ||||||
日付 | 2010-02-05 | |||||
日付タイプ | Created | |||||
発行日 | ||||||
日付 | 2007 | |||||
日付タイプ | Created | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | 1497737 bytes | |||||
公開範囲 | ||||||
値 | 学外 | |||||
著者所属 | ||||||
東北大学医学部保健学科検査技術科学専攻病理検査学@@@Department of Pathology, Tohoku University School of Health Sciences | ||||||
更新日 | ||||||
日付 | 2010-02-05 | |||||
日付タイプ | Created |