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舌粘膜上皮増殖性疾患とヒト乳頭腫ウイルス(HPV)感染の相関性について : 非放射性in situ hybridization(non-RI ISH)法
http://hdl.handle.net/10097/31455
http://hdl.handle.net/10097/31455d5018d18-98ad-4ed9-8ffe-b0df8031647f
名前 / ファイル | ライセンス | アクション |
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KJ00000093462.pdf (922.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-05-02 | |||||
タイトル | ||||||
タイトル | 舌粘膜上皮増殖性疾患とヒト乳頭腫ウイルス(HPV)感染の相関性について : 非放射性in situ hybridization(non-RI ISH)法 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | human papillomavirus (HPV) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in situ hybridization(ISH) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tongue | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | stratified squamous epithelium | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | proliferative lesions | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
熊本, 裕行
× 熊本, 裕行× 清水, 良央× 大家, 清 |
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著者(ヨミ) | ||||||
姓名 | Kumamoto, Hiroyuki | |||||
著者(ヨミ) | ||||||
姓名 | Shimizu, Yoshinaka | |||||
著者(ヨミ) | ||||||
姓名 | Ooya, Kiyoshi | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | ヒト乳頭腫ウイルス(HPV)は, パポバウイルス科に属する二重鎖DNAウイルスで, 皮膚・粘膜への感染により重層扁平上皮の増殖に関与する。本研究では非放射性in situ hybridization(non-RIISH)法により, 舌粘膜上皮増殖性疾患について検討した。プローブはHPV6・11・16・18・30・31・32・35・45・51型に共通するcDNAをビオチン化したものを用いた。HPVDNAは上皮細胞の核ないし核および核周囲の細胞質で検出された。正常上皮では3例中1例にHPVが検出され, 潜伏感染が示された。乳頭腫では3例すべてにHPVが検出され, その病原性が示唆された。白板症では3例中1例に, 涜賛性癌では2例中1例に, 扁平上皮癌では3例中1例にHPVが検出された。これらの疾患とHPV感染の相関性は明瞭でなかった。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Human papillomaviruses (HPV) are double-stranded DNA viruses classified as members of the papovavirus family, and HPV infections are associated with proliferation of stratified squamous epithelium on skin and mucosa.In the present study, proliferative lesions of lingual stratified squamous epithelium were investigated using nonradioisotopic in situ hybridization (non-RI ISH) technique.Employed probes were biotinylated cDNAs of HPV types 6,11,16,18,30,31,33,35,45,51 and 52.HPV DNA signals were detected in the nuclei and/or both nuclei and perinuclear cytoplasms of epithelial cells.On normal epithelium, HPV DNA signals were detected in one of three cases and latent infections were confirmed. On papilloma HPV DNA signals were detected in all three cases, and HPV infections were considered to be correlated with the etiology.Leukoplakia showed positivity in one of three cases, verrucous carcinoma in one of two cases, and squamous cell carcinoma in one of three cases.The correlation between these lesions and HPV infections was obscure. | |||||
書誌情報 |
東北大学歯学雑誌 巻 12, 号 2, p. 87-91, 発行日 1993-12-28 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02873915 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00081101 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | Detection of human papillomavirus (HPV) DNA associated with proliferative lesions of lingual stratified squamous epithelium : Analysis using non-radioisotopic in situ hybridization (non-Rl ISH) technique | |||||
出版者 | ||||||
出版者 | 東北大学歯学会 | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 紀要類(bulletin) | |||||
登録日 | ||||||
日付 | 2008-05-02 | |||||
日付タイプ | Created | |||||
公開日(投稿完了日) | ||||||
日付 | 2008-05-02 | |||||
日付タイプ | Created | |||||
発行日 | ||||||
日付 | 1993-12-28 | |||||
日付タイプ | Created | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | 922064 bytes | |||||
公開範囲 | ||||||
値 | 学外 | |||||
更新日 | ||||||
日付 | 2010-01-27 | |||||
日付タイプ | Created |