| Item type |
紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2008-05-02 |
| タイトル |
|
|
タイトル |
Swine Intestinal Immunity via Toll-like Receptors and Its Advanced Application to Food Immunology |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 |
KITAZAWA, Haruki
SHIMOSATO, Takeshi
TOHNO, Masanori
SAITO, Tadao
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Recent interest has focused on the importance of intestinal immunity for the host defense, but to date, not much has been known about the underlying mechanisms. Toll-like receptor (TLR) family plays an important role in the defense through recognizing bacterial pathogen associated molecular patterns (PAMPs). Our research on the bioregulatory function of food products has investigated the immunoregulatory effects of lactic acid bacteria (LAB) via TLRs. Studies in swine, which is expected as a human model, have been examined intestinal immunoregulation by the LAB. Our research has now demonstrated modulation of intestinal immunity mediated by TLRs in Peyer's patches and the mesenteric lymph nodes. On the basis of our study, efforts have also been made to develop an immunoassay system for immunobiotic LAB DNA and cell wall components to evaluate immunoregulation by the LAB via TLRs. The findings in our research activities may provide important clues at the molecular level on TLR signal transduction pathways and recognition mechanisms. They also provide impetus to further delineate the activation mechanism of the innate immune response. In addition, identification of biofactors from LAB with immunoactivity, and better understanding of cytokine induction and intestinal immune regulation hold promise in basic research and development of "immunobiotic foods" to prevent specific diseases. |
| 書誌情報 |
Journal of Integrated Field Science
巻 3,
p. 9-14,
発行日 2006-03
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2433-6122 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12005506 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
Field Science Center, Graduate School of Agricultural Science, Tohoku University |
| 資源タイプ |
|
|
内容記述タイプ |
Other |
|
内容記述 |
紀要類(bulletin) |
| 登録日 |
|
|
日付 |
2008-05-02 |
|
日付タイプ |
Created |
| 公開日（投稿完了日） |
|
|
日付 |
2008-05-02 |
|
日付タイプ |
Created |
| 発行日 |
|
|
日付 |
2006-03 |
|
日付タイプ |
Created |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
778559 bytes |
| 更新日 |
|
|
日付 |
2018-01-04 |
|
日付タイプ |
Created |
KJ00004370124.pdf (778.6 kB)
